嗜亲性和异嗜性鼠白血病病毒体外感染后GIX抗原和总细胞表面抗原的诱导

Induction of GIX antigen and gross cell surface antigen after infection by ecotropic and xenotropic murine leukemia viruses in vitro.

作者信息

O'Donnell P V, Stockert E

出版信息

J Virol. 1976 Dec;20(3):545-54. doi: 10.1128/JVI.20.3.545-554.1976.

DOI:10.1128/JVI.20.3.545-554.1976

PMID:62848

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC355030/

Abstract

A number of ecotropic and xenotropic murine leukemia viruses were examined for their ability to induce the GIX antigen and Gross cell surface antigen (GCSA) in tissue culture fibroblasts. GIX appears to be a constituent of murine leukemia virus gp70; a molecular characterization of GCSA has not yet been reported. Antigen induction was measured by the ability of productively infected cells to absorb cytotoxic activity from the standard GIX- and GCSA-typing antisera. Cells infected by ecotropic viruses displayed four distinct phenotypes GIX:+/GCSA++, GIX-/GCSA++, GIX++/GCSA+, and GIX-/GSCA+; cells infected by xenotropic viruses were either GIX-/GCSA+ or GIX-/GCSA-. GIX induction appeared to be a type-specific property of some but not all Gross-AKR type ecotropic viruses. Differences in the degree of absorption of the GCSA antiserum by ecotropic virus- and xenotropic virus-infected cells indicated that GCSA may comprise multiple antigenic determinants.

摘要

检测了多种嗜亲性和异嗜性鼠白血病病毒在组织培养成纤维细胞中诱导GIX抗原和格罗斯细胞表面抗原（GCSA）的能力。GIX似乎是鼠白血病病毒gp70的一个组成部分；尚未有关于GCSA的分子特征报道。通过产生感染的细胞从标准GIX和GCSA分型抗血清中吸收细胞毒性活性的能力来测定抗原诱导情况。受嗜亲性病毒感染的细胞表现出四种不同的表型：GIX+/GCSA++、GIX-/GCSA++、GIX++/GCSA+和GIX-/GSCA+；受异嗜性病毒感染的细胞要么是GIX-/GCSA+，要么是GIX-/GCSA-。GIX诱导似乎是某些但并非所有格罗斯 - AKR型嗜亲性病毒的一种型特异性特性。嗜亲性病毒和异嗜性病毒感染的细胞对GCSA抗血清吸收程度的差异表明，GCSA可能包含多个抗原决定簇。

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