Wirz-Justice A, Kafka M S, Naber D, Campbell I C, Marangos P J, Tamarkin L, Wehr T A
Brain Res. 1982 Jun 3;241(1):115-22. doi: 10.1016/0006-8993(82)91234-3.
The number of alpha- and beta-adrenergic, muscarinic cholinergic, opiate, and benzodiazepine receptors in rat forebrain, and dopamine and benzodiazepine receptors in striatum, change throughout the day. The diurnal rhythms of these receptors were altered by treatment with the monoamine-oxidase inhibitor clorgyline: following treatment some or all rhythm characteristics of wave form, amplitude, 24-h mean, and phase, were affected. One common effect of treatment was a delay in phase-position of binding to alpha- and beta-adrenergic, opiate and benzodiazepine receptors. Additionally, the nocturnal elevation in pineal melatonin which normally returns to baseline at light onset, persisted 3 h into the light period after clorgyline administration. These biochemical observations extend behavioural findings that clorgyline can delay the phase-position of rodent nocturnal activity onset, and does so by slowing the central circadian pacemaker.
大鼠前脑中α-和β-肾上腺素能、毒蕈碱胆碱能、阿片类和苯二氮䓬受体的数量，以及纹状体中的多巴胺和苯二氮䓬受体的数量，在一天中会发生变化。单胺氧化酶抑制剂氯吉兰的治疗改变了这些受体的昼夜节律：治疗后，波形、振幅、24小时平均值和相位的一些或所有节律特征都受到了影响。治疗的一个常见效果是与α-和β-肾上腺素能、阿片类和苯二氮䓬受体结合的相位延迟。此外，松果体褪黑素的夜间升高通常在光照开始时恢复到基线水平，但在给予氯吉兰后，在光照期持续了3小时。这些生化观察结果扩展了行为学研究结果，即氯吉兰可以延迟啮齿动物夜间活动开始的相位，并且是通过减慢中枢昼夜节律起搏器来实现的。
