Robberecht P, Waelbroeck M, Noyer M, Chatelain P, De Neef P, König W, Christophe J
Digestion. 1982;23(3):201-10. doi: 10.1159/000198728.
A comparison has been made of the ability of vasoactive intestinal peptide (VIP), secretin, secretin analogues, and secretin-(7-27) to stimulate adenylate cyclase in rat pancreatic plasma membranes. A parallel study of the capacity of peptides of the VIP-secretin family to compete with 125I-VIP for binding to the same plasma membranes was conducted. This allowed a classification of VIP-secretin receptors into three subtypes: (1) VIP-preferring receptors; (2) high-affinity secretin receptors, and (3) low-affinity secretin receptors. The properties of secretin at high-affinity secretin receptors were likely to reflect a contribution of membranes from centroacinar and duct cells.
对血管活性肠肽（VIP）、促胰液素、促胰液素类似物以及促胰液素-（7-27）刺激大鼠胰腺质膜中腺苷酸环化酶的能力进行了比较。同时对VIP-促胰液素家族肽与125I-VIP竞争结合同一质膜的能力进行了平行研究。这使得VIP-促胰液素受体可分为三种亚型：（1）优先结合VIP的受体；（2）高亲和力促胰液素受体；（3）低亲和力促胰液素受体。高亲和力促胰液素受体上促胰液素的特性可能反映了中央腺泡细胞和导管细胞膜的作用。
