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1
Phosphatidylinositol-hydrolysing enzymes in blowfly salivary glands.绿头苍蝇唾液腺中的磷脂酰肌醇水解酶。
Biochem J. 1982 Apr 15;204(1):361-4. doi: 10.1042/bj2040361.
2
Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland.丽蝇唾液腺中磷脂酰肌醇水解的激素激活、液体分泌与钙通量之间的关系。
Biochem J. 1979 Jan 15;178(1):45-58. doi: 10.1042/bj1780045.
3
Phosphoinositide breakdown in blowfly salivary glands.绿头苍蝇唾液腺中的磷酸肌醇分解
Am J Physiol. 1984 Jan;246(1 Pt 1):C141-7. doi: 10.1152/ajpcell.1984.246.1.C141.
4
Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands.家蝇唾液腺中磷脂酰肌醇合成与5-羟色胺反应性Ca2+通量恢复之间的关系。
Biochem J. 1979 Jun 15;180(3):655-61. doi: 10.1042/bj1800655.
5
5-Methyltryptamine stimulates phospholipase C-mediated breakdown of exogenous phosphoinositides by blowfly salivary gland membranes.
J Biol Chem. 1985 Dec 25;260(30):16052-5.
6
Phosphoinositide synthesis and Ca2+ gating in blowfly salivary glands exposed to 5-hydroxytryptamine.暴露于5-羟色胺的丽蝇唾液腺中的磷酸肌醇合成与Ca2+门控
Biochem J. 1984 Sep 1;222(2):327-34. doi: 10.1042/bj2220327.
7
The catabolism of phosphatidylinisitol by an EDTA-insensitive phospholipase A1 and calcium-dependent phosphatidylinositol phosphodiesterase in rat brain.大鼠脑中一种对乙二胺四乙酸不敏感的磷脂酶A1和钙依赖性磷脂酰肌醇磷酸二酯酶对磷脂酰肌醇的分解代谢。
Eur J Biochem. 1981 Nov;120(1):53-8. doi: 10.1111/j.1432-1033.1981.tb05669.x.
8
5-HT-stimulated arachidonic acid release from labeled phosphatidylinositol in blowfly salivary glands.5-羟色胺刺激家蝇唾液腺中标记磷脂酰肌醇释放花生四烯酸。
Am J Physiol. 1982 Nov;243(5):C222-6. doi: 10.1152/ajpcell.1982.243.5.C222.
9
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.肌醇三磷酸的快速积累表明，激动剂水解多磷酸肌醇而非磷脂酰肌醇。
Biochem J. 1983 Jun 15;212(3):849-58. doi: 10.1042/bj2120849.
10
[Cooperation of the functioning of phospholipase A2 and phosphoinositide-specific phosphodiesterase from rat brain synaptosomes during initiation of the phosphoinositide cycle].
Dokl Akad Nauk SSSR. 1987;295(5):1254-7.

引用本文的文献

1
From GTP and G proteins to TRPC channels: a personal account.从GTP和G蛋白到瞬时受体电位通道（TRPC）：个人视角
J Mol Med (Berl). 2015 Sep;93(9):941-53. doi: 10.1007/s00109-015-1328-5. Epub 2015 Sep 16.
2
Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast.从盘基网柄菌中鉴定出磷脂酶B，揭示了一个存在于哺乳动物、果蝇和线虫但不存在于酵母中的新脂肪酶家族。
Biochem J. 2004 Sep 1;382(Pt 2):441-9. doi: 10.1042/BJ20040110.
3
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.肌醇三磷酸的快速积累表明，激动剂水解多磷酸肌醇而非磷脂酰肌醇。
Biochem J. 1983 Jun 15;212(3):849-58. doi: 10.1042/bj2120849.

本文引用的文献

1
Thyrotropin-stimulated phosphatidylinositol-specific phospholipase A2 in pig thyroid, a re-examination.
FEBS Lett. 1980 Oct 6;119(2):287-9. doi: 10.1016/0014-5793(80)80273-0.
2
The hydrolysis of phosphatidylinositol monolayers at an air/water interface by the calcium-ion-dependent phosphatidylinositol phosphodiesterase of pig brain.猪脑钙离子依赖性磷脂酰肌醇磷酸二酯酶对空气/水界面磷脂酰肌醇单层的水解作用。
Biochem J. 1981 Feb 1;193(2):607-14. doi: 10.1042/bj1930607.
3
The inhibition and activation of Ca2+-dependent phosphatidylinositol phosphodiesterase by phospholipids and blood plasma.磷脂和血浆对钙离子依赖性磷脂酰肌醇磷酸二酯酶的抑制与激活作用
Eur J Biochem. 1980 Nov;112(1):33-8. doi: 10.1111/j.1432-1033.1980.tb04983.x.
4
The selective loss of lysophospholipids in some commonly used lipid-extraction procedures.某些常用脂质提取方法中溶血磷脂的选择性损失。
Anal Biochem. 1974 Mar;58(1):238-45. doi: 10.1016/0003-2697(74)90463-1.
5
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase.D-肌醇1:2-环磷酸酯2-磷酸水解酶
Biochem J. 1972 Mar;127(1):113-8. doi: 10.1042/bj1270113.
6
Characterization of glycerophosphorylcholine, -ethanolamine, -serine, -inositol, and -glycerol hydrolytic activity in housefly larvae.家蝇幼虫中甘油磷酸胆碱、甘油磷酸乙醇胺、甘油磷酸丝氨酸、甘油磷酸肌醇和甘油水解活性的表征
J Lipid Res. 1972 May;13(3):348-55.
7
Metabolism of ceramide phosphorylethanolamine, phosphatidylinositol, phosphatidylserine and phosphatidylglycerol by housefly larvae.家蝇幼虫对神经酰胺磷酸乙醇胺、磷脂酰肌醇、磷脂酰丝氨酸和磷脂酰甘油的代谢
Lipids. 1971 Jul;6(7):508-16. doi: 10.1007/BF02531237.
8
Insect salivary glands: stimulation of fluid secretion by 5-hydroxytryptamine and adenosine-3',5'-monophosphate.昆虫唾液腺：5-羟色胺和3',5'-环磷酸腺苷对液体分泌的刺激作用
Science. 1968 Oct 25;162(3852):462-3. doi: 10.1126/science.162.3852.462.
9
The hydrolysis of phosphatidylinositol by lysosomal enzymes of rat liver and brain.大鼠肝脏和大脑的溶酶体酶对磷脂酰肌醇的水解作用。
Biochem J. 1978 Nov 15;176(2):475-84. doi: 10.1042/bj1760475.
10
Transfer of arachidonic acid between phospholipids in rat liver microsomes.大鼠肝微粒体中磷脂间花生四烯酸的转移
Biochem Biophys Res Commun. 1979 Dec 28;91(4):1399-405. doi: 10.1016/0006-291x(79)91222-1.

绿头苍蝇唾液腺中的磷脂酰肌醇水解酶。

Phosphatidylinositol-hydrolysing enzymes in blowfly salivary glands.

作者信息

Irvine R F, Berridge M J, Letcher A J, Dawson R M

出版信息

Biochem J. 1982 Apr 15;204(1):361-4. doi: 10.1042/bj2040361.

DOI:10.1042/bj2040361
PMID:6288018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1158354/
Abstract

The salivary glands of adult blowflies (Calliphora erythrocephala) contain enzymes that hydrolyse phosphatidylinositol, predominantly by a Ca2+-independent deacylation, though a Ca2+-dependent phosphodiesterase (phospholipase C) activity could be detected. The deacylating enzymes could also hydrolyse phosphatidylcholine and phosphatidylethanolamine, and were secreted in the saliva. Homogenization of salivary glands prelabelled with [3H]inositol resulted in a rapid deacylation of the endogenous 3H-labelled phosphatidylinositol; this hydrolysis was unaffected by addition of 5-hydroxytryptamine to the homogenate.

摘要

成年红头丽蝇（Calliphora erythrocephala）的唾液腺含有能水解磷脂酰肌醇的酶，主要通过不依赖Ca2+的脱酰作用，不过也能检测到依赖Ca2+的磷酸二酯酶（磷脂酶C）活性。脱酰酶也能水解磷脂酰胆碱和磷脂酰乙醇胺，并分泌到唾液中。用[3H]肌醇预标记的唾液腺匀浆导致内源性3H标记的磷脂酰肌醇快速脱酰；向匀浆中添加5-羟色胺不影响这种水解作用。