Gunne L M, Growdon J H
J Clin Psychopharmacol. 1982 Oct;2(5):308-11.
Rats subjected to bifrontal cortical ablations developed vacuous chewing movements and jaw tremors that began 22 weeks after surgery, reached a peak rate of 4 to 8 per minute, and remained stable for an 8-week observation period. Chronic haloperidol administration to rats with bifrontal cortical ablations produced 15 to 20 movements per minute that persisted for 7 weeks after drug withdrawal. Drugs given to decrease dopaminergic, cholinergic, and gamma-aminobutyric acid (GABA)-ergic neurotransmission suppressed the movements, whereas cholinergic agonists increased them. This model of oral dyskinesia in rats may be useful in developing drugs for the treatment of facial dyskinesias in humans.
接受双侧额叶皮质切除的大鼠出现了空嚼运动和下颌震颤，这些症状在手术后22周开始出现，每分钟达到4至8次的峰值，并在8周的观察期内保持稳定。对接受双侧额叶皮质切除的大鼠长期给予氟哌啶醇，停药后每分钟会产生15至20次运动，持续7周。用于减少多巴胺能、胆碱能和γ-氨基丁酸（GABA）能神经传递的药物可抑制这些运动，而胆碱能激动剂则会增强这些运动。大鼠的这种口部运动障碍模型可能有助于开发治疗人类面部运动障碍的药物。
