衰老诱导下丘脑-垂体轴中β-内啡肽和甲硫氨酸脑啡肽含量的变化。

Changes of beta-endorphin and Met-enkephalin content in the hypothalamus-pituitary axis induced by aging.

作者信息

Missale C, Govoni S, Croce L, Bosio A, Spano P F, Trabucchi M

出版信息

J Neurochem. 1983 Jan;40(1):20-4. doi: 10.1111/j.1471-4159.1983.tb12647.x.

DOI:10.1111/j.1471-4159.1983.tb12647.x

Abstract

The amounts of beta-endorphin- and Met-enkephalin-immunoreactive material are higher in the pituitary of aged rats. However, the aging process decreases the content of beta-endorphin-, but does not affect that of Met-enkephalin-immunoreactive material, in hypothalamus. Thus, it seems that the regulatory mechanisms in the two areas are differentially affected by increasing age. On the other hand, the pituitary increase of these peptides is in line with the assumption that in the elderly the hormonal response to stress is impaired.

摘要

老年大鼠垂体中β-内啡肽和甲硫氨酸脑啡肽免疫反应性物质的含量较高。然而，衰老过程会降低下丘脑β-内啡肽的含量，但不影响甲硫氨酸脑啡肽免疫反应性物质的含量。因此，似乎这两个区域的调节机制受年龄增长的影响不同。另一方面，这些肽在垂体中的增加符合老年人对应激的激素反应受损这一假设。