由爱泼斯坦-巴尔病毒（EBV）转化的人B细胞中线粒体DNA的复杂形式。
Complex forms of mitochondrial DNA in human B cells transformed by Epstein-Barr virus (EBV).
作者信息
Christiansen G, Christiansen C, Zeuthen J
出版信息
J Cancer Res Clin Oncol. 1983;105(1):13-9. doi: 10.1007/BF00391825.
Abstract
Human lymphocytes and lymphoid cell lines were analyzed for the presence of complex forms of mitochondrial DNA (mtDNA) by electron microscopy. A high frequency (9%-14.5%) of catenated dimers, circular dimers, or oligomers were found in samples from Epstein-Barr-virus-(EBV) transformed lymphoblastoid cell lines. These complex forms of mtDNA were present in much lower frequencies in lymphocytes isolated from donor blood (1.3%-4.6%). Similar low frequencies were found with primary fibroblasts (1.1%) or freshly isolated monkey liver cells (2.1%). Samples from cultures of Burkitt lymphoma (BL) cell lines of EBV-positive or -negative origin contained intermediate (5%-7%) frequencies of complex forms of mtDNA.
摘要
通过电子显微镜分析人淋巴细胞和淋巴样细胞系，以检测线粒体DNA（mtDNA）复杂形式的存在情况。在来自爱泼斯坦-巴尔病毒（EBV）转化的淋巴母细胞系的样本中，发现了高频（9%-14.5%）的连环二聚体、环状二聚体或寡聚体。这些mtDNA的复杂形式在从供血者血液中分离出的淋巴细胞中出现的频率要低得多（1.3%-4.6%）。在原代成纤维细胞（1.1%）或新鲜分离的猴肝细胞（2.1%）中也发现了类似的低频率。来自EBV阳性或阴性来源的伯基特淋巴瘤（BL）细胞系培养物的样本中，mtDNA复杂形式的频率处于中等水平（5%-7%）。
相似文献
1
Complex forms of mitochondrial DNA in human B cells transformed by Epstein-Barr virus (EBV).由爱泼斯坦-巴尔病毒（EBV）转化的人B细胞中线粒体DNA的复杂形式。
J Cancer Res Clin Oncol. 1983;105(1):13-9. doi: 10.1007/BF00391825.
2
Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolism.爱泼斯坦-巴尔病毒潜伏膜蛋白1破坏肌苷酸脱氢酶途径以驱动B细胞肿瘤代谢。
PLoS Pathog. 2025 May 14;21(5):e1013092. doi: 10.1371/journal.ppat.1013092. eCollection 2025 May.
3
Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically.卡波西肉瘤相关疱疹病毒与爱泼斯坦-巴尔病毒协同作用，对一小部分人类B细胞进行致癌性共转化。
PLoS Pathog. 2025 Jun 23;21(6):e1013281. doi: 10.1371/journal.ppat.1013281. eCollection 2025 Jun.
4
Dimer-size DNA circles in a leukemic cell immortalized with the Epstein-Barr virus.用爱泼斯坦-巴尔病毒永生化的白血病细胞中的二聚体大小的DNA环。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4770-4. doi: 10.1073/pnas.79.15.4770.
5
Synergistic effect of Epstein-Barr virus and tumor promoters on induction of lymphoma and carcinoma in nude mice.爱泼斯坦-巴尔病毒与肿瘤启动子对裸鼠淋巴瘤和癌诱导的协同作用。
J Cancer Res Clin Oncol. 1998;124(10):541-8. doi: 10.1007/s004320050212.
6
Sustained activation induced cytidine deaminase (AID) expression in B cells following Plasmodium falciparum malaria infection in Kenyan children.肯尼亚儿童感染恶性疟原虫疟疾后，持续激活诱导B细胞中胞苷脱氨酶（AID）表达。
J Immunol. 2025 May 1;214(5):926-935. doi: 10.1093/jimmun/vkaf005.
7
Epstein-Barr virus type 2 infection is associated with higher viral loads in pediatric tonsils from western Kenya.2型爱泼斯坦-巴尔病毒感染与肯尼亚西部儿童扁桃体中更高的病毒载量相关。
Microbiol Spectr. 2025 Aug 5;13(8):e0074025. doi: 10.1128/spectrum.00740-25. Epub 2025 Jul 8.
8
EBNA leader protein orchestrates chromatin architecture remodeling during Epstein-Barr virus-induced B cell transformation.EBNA 前导蛋白在爱泼斯坦-巴尔病毒诱导的 B 细胞转化过程中协调染色质结构重塑。
Nucleic Acids Res. 2025 Jun 20;53(12). doi: 10.1093/nar/gkaf629.
9
T cell-mediated immune surveillance conferred by latent Epstein-Barr virus genes suppresses a broad spectrum of tumor formation through NKG2D-NKG2DL interactions.潜伏的爱泼斯坦-巴尔病毒基因赋予的T细胞介导的免疫监视通过NKG2D-NKG2DL相互作用抑制广泛的肿瘤形成。
Front Immunol. 2025 Jun 4;16:1597731. doi: 10.3389/fimmu.2025.1597731. eCollection 2025.
10
Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis.结核菌素通过诱导活性氧杀死爱泼斯坦-巴尔病毒（EBV）-伯基特淋巴瘤细胞，并通过诱导凋亡杀死EBV淋巴母细胞。
J Biol Chem. 2009 Jun 19;284(25):17102-17109. doi: 10.1074/jbc.M809090200. Epub 2009 Apr 22.
引用本文的文献
1
Brain Atrophy and White Matter Damage Linked to Peripheral Bioenergetic Deficits in the Neurodegenerative Disease FXTAS.神经退行性疾病 FXTAS 中与周围生物能量缺陷相关的脑萎缩和白质损伤。
Int J Mol Sci. 2021 Aug 25;22(17):9171. doi: 10.3390/ijms22179171.
2
Epstein-Barr virus (EBV), lymphocytes and transformation.爱泼斯坦-巴尔病毒（EBV）、淋巴细胞与转化
J Cancer Res Clin Oncol. 1983;106(1):1-11. doi: 10.1007/BF00399890.
本文引用的文献
1
A STUDY OF MALIGNANT TUMOURS IN NIGERIA BY SHORT-TERM TISSUE CULTURE.尼日利亚恶性肿瘤的短期组织培养研究
J Clin Pathol. 1965 May;18(3):261-73. doi: 10.1136/jcp.18.3.261.
2
SEPARATION OF WHITE BLOOD CELLS.白细胞的分离
Nature. 1964 Nov 21;204:793-4. doi: 10.1038/204793a0.
3
Sequence and organization of the human mitochondrial genome.人类线粒体基因组的序列与组织
Nature. 1981 Apr 9;290(5806):457-65. doi: 10.1038/290457a0.
4
Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes.人白血病白细胞中线粒体DNA的环状二聚体和连环体形式
Nature. 1967 Nov 18;216(5116):652-7. doi: 10.1038/216652a0.
5
Catenated circular DNA molecules in HeLa cell mitochondria.HeLa细胞线粒体中的连环环状DNA分子。
Nature. 1967 Nov 18;216(5116):647-52. doi: 10.1038/216647a0.
6
Replication of mitochondrial DNA in mouse L cells and their thymidine kinase - derivatives: displacement replication on a covalently-closed circular template.小鼠L细胞及其胸苷激酶衍生物中线粒体DNA的复制：共价闭合环状模板上的置换复制
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3810-4. doi: 10.1073/pnas.69.12.3810.
7
Release of infectious Epstein-Barr virus by transformed marmoset leukocytes.转化的狨猴白细胞释放传染性爱泼斯坦-巴尔病毒。
Proc Natl Acad Sci U S A. 1973 Jan;70(1):190-4. doi: 10.1073/pnas.70.1.190.
8
Identification of human chromosomes by DNA-binding fluorescent agents.利用DNA结合荧光剂鉴定人类染色体
Chromosoma. 1970;30(2):215-27. doi: 10.1007/BF00282002.
9
Marker band in one chromosome 14 from Burkitt lymphomas.伯基特淋巴瘤14号染色体上的标记带。
Nature. 1972 May 5;237(5349):33-4. doi: 10.1038/237033a0.
10
The selection of somatic cell hybrids between human lymphoma cell lines.人淋巴瘤细胞系之间体细胞杂种的选择。
Somatic Cell Genet. 1976 Jul;2(4):309-24. doi: 10.1007/BF01538836.
Zotero 插件