长期使用β-咔啉-3-羧酸乙酯后，脑内苯二氮䓬受体增加。
Brain benzodiazepine receptors increase after chronic ethyl-beta-carboline-3-carboxylate.
作者信息
Concas A, Salis M, Biggio G
出版信息
Life Sci. 1983 Mar 14;32(11):1175-82. doi: 10.1016/0024-3205(83)90185-6.
Rats were treated with repeated intraventricular injections of ethyl-beta-carboline-3-carboxylate (beta-CCE) (10 micrograms/rat, twice daily for 8 days), 36 h after the last injection, the total number of 3H-diazepam binding sites was increased in the cerebral cortex, cerebellum and hippocampus by 63, 51 and 38%, respectively. On the other hand, there were no significant differences in the dissociation constants (KD) between beta-CCE and solvent treated rats. In contrast, chronic beta-CCE administration failed to change the number of the apparent affinity of 3H-beta-CCE binding sites in all the brain areas examined. The results suggest that beta-CCE is an antagonist at the 3H-diazepam binding sites.
给大鼠反复脑室内注射β-咔啉-3-羧酸乙酯（β-CCE）（10微克/只，每日两次，共8天），末次注射36小时后，大脑皮层、小脑和海马中3H-地西泮结合位点总数分别增加了63%、51%和38%。另一方面，β-CCE处理组大鼠与溶剂处理组大鼠之间的解离常数（KD）无显著差异。相比之下，长期给予β-CCE未能改变所有检测脑区中3H-β-CCE结合位点的表观亲和力数量。结果表明，β-CCE是3H-地西泮结合位点的拮抗剂。
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