Mondrup K, Pedersen E
Acta Neurol Scand. 1983 Jan;67(1):48-54. doi: 10.1111/j.1600-0404.1983.tb04544.x.
THIP (Lu 2-030) is pharmacologically a specific and potent GABA-receptor-agonist which in animal studies depresses monosynaptic and, to a smaller extent, polysynaptic spinal reflexes. 5 spastic patients were investigated by means of neurophysiological tests comparing the acute effect of a single oral dose of THIP (15-25 mg) to "the test situation without drug administration" with an interval of 2 days. The neurophysiological tests included quantitative studies of proprioceptive reflexes (T-reflex, vibratory inhibition of the T-reflex, resistance to passive movement of a spastic muscle and clonus) and of the flexor reflex (threshold and latency). The voluntary power was measured by a static technique. THIP clearly reduced the monosynaptic T-reflex and reinforced vibratory inhibition of the IA monosynaptic pathway. The flexor reflex threshold was slightly increased during THIP administration, but the changes were not significant. Flexor reflex latency, resistance to passive movement, clonus and voluntary power were unchanged.
THIP（鲁2 - 030）在药理学上是一种特异性强效GABA受体激动剂，在动物研究中可抑制单突触以及在较小程度上抑制多突触脊髓反射。通过神经生理学测试对5名痉挛患者进行了研究，比较单次口服THIP（15 - 25毫克）与“未给药测试情况”的急性效应，间隔为2天。神经生理学测试包括对本体感觉反射（T反射、T反射的振动抑制、痉挛肌肉被动运动的阻力和阵挛）以及屈肌反射（阈值和潜伏期）的定量研究。通过静态技术测量自愿力量。THIP明显降低了单突触T反射，并增强了IA单突触通路的振动抑制。在服用THIP期间，屈肌反射阈值略有增加，但变化不显著。屈肌反射潜伏期、被动运动阻力、阵挛和自愿力量均未改变。
