血小板活化因子乙酰醚和白三烯B4的中性粒细胞聚集特性。

Neutrophil aggregating properties of PAF-acether and leukotriene B4.

作者信息

Ford-Hutchinson A W

出版信息

Int J Immunopharmacol. 1983;5(1):17-21. doi: 10.1016/0192-0561(83)90067-x.

PMID:6302012

Abstract

Both leukotriene B4 (LTB4) and platelet activating factor (PAF-acether) induce the aggregation of rat polymorphonuclear leucocytes. PAF-acether, but not LTB4, causes the aggregation of washed rabbit platelets. The results obtained from cross-desensitisation studies and experiments using inhibitors of arachidonic acid metabolism support the concept that LTB4 and PAF-acether have separate receptor sites on the neutrophil cell surface and show that PAF-acether does not induce neutrophil aggregation by releasing LTB4.

摘要

白三烯B4（LTB4）和血小板活化因子（PAF-乙醚）均可诱导大鼠多形核白细胞聚集。PAF-乙醚可引起洗涤过的兔血小板聚集，而LTB4则不能。交叉脱敏研究和使用花生四烯酸代谢抑制剂的实验结果支持以下观点：LTB4和PAF-乙醚在中性粒细胞表面具有不同的受体位点，并且表明PAF-乙醚不会通过释放LTB4来诱导中性粒细胞聚集。