Gilliam D M, Collins A C
Pharmacol Biochem Behav. 1983 May;18(5):803-8. doi: 10.1016/0091-3057(83)90026-6.
Circadian variations in response to ethanol were studied in long-sleep (LS) and short-sleep (SS) mice. Each LS animal received a 2.5 g/kg intraperitoneal ethanol injection, while the SS animals were injected with 4.1 or 5.0 g/kg. Different groups of mice were assessed for sleep time, waking blood alcohol concentration (BAC), and waking brain ethanol concentration (BREC) at 03.00, 09.00, 15.00, or 21.00 hr. Sleep times, waking BACs, and waking BRECs showed circadian variations in the LS mice. SS animals given the 4.1 g/kg dose showed circadian variations for waking BAC and waking BREC, but not for sleep time. The observed variations in the physiological parameters for these animals may have been confounded by a short sleep time so that they reflected circadian variations in drug absorption and/or distribution rather than in CNS sensitivity. SS mice given the 5.0 g/kg dose slept longer than those given the 4.1 g/kg dose and did not show circadian variations for sleep time, waking BAC, or waking BREC. These results suggest both circadian and genetic influences on tissue sensitivity to ethanol.
在长睡眠（LS）和短睡眠（SS）小鼠中研究了对乙醇反应的昼夜节律变化。每只LS小鼠接受2.5 g/kg的腹腔内乙醇注射，而SS小鼠则注射4.1或5.0 g/kg。在03:00、09:00、15:00或21:00时对不同组的小鼠进行睡眠时间、清醒时血液酒精浓度（BAC）和清醒时脑乙醇浓度（BREC）的评估。睡眠时间、清醒时BAC和清醒时BREC在LS小鼠中表现出昼夜节律变化。给予4.1 g/kg剂量的SS小鼠清醒时BAC和清醒时BREC表现出昼夜节律变化，但睡眠时间没有。这些动物生理参数的观察到的变化可能因睡眠时间短而混淆，以至于它们反映的是药物吸收和/或分布的昼夜节律变化，而不是中枢神经系统敏感性的变化。给予5.0 g/kg剂量的SS小鼠比给予4.1 g/kg剂量的小鼠睡眠时间更长，并且睡眠时间、清醒时BAC或清醒时BREC均未表现出昼夜节律变化。这些结果表明昼夜节律和遗传因素对组织对乙醇的敏感性均有影响。
