内分泌疾病中的自身免疫

Autoimmunity in endocrine diseases.

作者信息

Rose N R, Burek C L

出版信息

Spec Top Endocrinol Metab. 1982;4:139-76.

Abstract

The realization that autoimmunity underlies many endocrine disorders of previously unknown etiology has greatly broadened our understanding of the pathogenesis of these diseases. It has provided new explanations for their heredity and their association with particular HLA haplotypes. It has also offered new tools for diagnosing these diseases as well as monitoring their course or predicting their outcome. Finally, establishing the autoimmune basis of these diseases offers new potential for their treatment. The next quarter century of research into immunologic aspects of endocrine diseases promises to be as fruitful as the last.

摘要

自身免疫是许多病因不明的内分泌疾病的基础，这一认识极大地拓宽了我们对这些疾病发病机制的理解。它为这些疾病的遗传因素以及与特定 HLA 单倍型的关联提供了新的解释。它还为诊断这些疾病、监测其病程或预测其结果提供了新的工具。最后，确定这些疾病的自身免疫基础为其治疗提供了新的潜力。未来四分之一个世纪对内分泌疾病免疫学方面的研究有望像过去一样富有成果。