孤立性促肾上腺皮质激素缺乏伴“原发性甲状腺功能减退症”和高催乳素血症。

Isolated ACTH deficiency accompanied by 'primary hypothyroidism' and hyperprolactinaemia.

作者信息

Yoshida T, Arai T, Sugano J, Yarita H, Yanagisawa H

出版信息

Acta Endocrinol (Copenh). 1983 Dec;104(4):397-401. doi: 10.1530/acta.0.1040397.

DOI:10.1530/acta.0.1040397

Abstract

A 55 year old man with isolated ACTH deficiency is reported. The lesion would appear to be located in the pituitary gland since plasma ACTH and cortisol did not respond to lysine vasopressin and corticotrophin releasing factor (CRF). A fall in T4, a rise in basal values of TSH, prolactin (Prl), LH and FSH, excessive responses of TSH and Prl to TRH, and hyperreactive responses of LH and FSH to LRH were observed. These hormonal changes were examined before and after administration of cortisol. The abnormality in these hormones might be caused by deficiency of long-term glucocorticoid.

摘要

报告了一名55岁孤立性促肾上腺皮质激素（ACTH）缺乏的男性患者。由于血浆促肾上腺皮质激素和皮质醇对赖氨酸加压素和促肾上腺皮质激素释放因子（CRF）无反应，病变似乎位于垂体。观察到甲状腺素（T4）下降，促甲状腺激素（TSH）、催乳素（Prl）、促黄体生成素（LH）和促卵泡生成素（FSH）基础值升高，TSH和Prl对促甲状腺激素释放激素（TRH）反应过度，LH和FSH对促性腺激素释放激素（LRH）反应亢进。在给予皮质醇前后检查了这些激素变化。这些激素异常可能是由于长期糖皮质激素缺乏所致。