孕酮对外周硫酸雌酮代谢影响的初步报告
Preliminary report on progesterone effect on peripheral estrone sulfate metabolism.
作者信息
Jasonni V M, Bulletti C, Franceschetti F, Ciotti P, Bonavia M, Ferraretti A P, Flamigni C
出版信息
Acta Eur Fertil. 1983 Mar-Apr;14(2):137-40.
PMID:6322502
Abstract
The effect of progesterone (P) on peripheral estrone sulfate (E1S) was investigated in postmenopausal women using E1S constant infusions. The metabolic clearance rate of E1S (MCRE1S) was significantly lowered by P administration (p less than 0.01), while no significant changes were observed for E1S----E1 conversion ratio. The present findings suggest that P can affect the E1S peripheral fate inducing deep changes in estrogen equilibrium.
摘要
通过持续输注硫酸雌酮（E1S），研究了孕酮（P）对绝经后女性外周硫酸雌酮（E1S）的影响。给予孕酮后，硫酸雌酮的代谢清除率（MCRE1S）显著降低（p<0.01），而硫酸雌酮向雌酮（E1）的转化率无显著变化。目前的研究结果表明，孕酮可影响硫酸雌酮在周围组织的代谢过程，从而引起雌激素平衡的深刻变化。
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