Dowler K W, Veltri R W
J Med Virol. 1984;13(3):251-9. doi: 10.1002/jmv.1890130307.
We designed experiments to assess the effects of binding of the HSV-2 Fc receptor (FcR) to purified rabbit nonimmune IgG and purified Fc. Purified Fc (75 micrograms) or nonimmune IgG (100 micrograms) when bound to HSV-2 did not reduce infectivity but did protect the virions against thermal inactivation at 37 degrees C. However, preincubation of these two reagents with HSV-2 virions significantly protected against neutralization by specific anti-HSV-2, F(ab')2 purified rabbit antiserum. The blockage of neutralization and protection against thermal inactivation afforded by FcR-Fc interaction on HSV-2 virions provide a tenable mechanism to explain viral persistence in an immune host.
我们设计了实验来评估单纯疱疹病毒2型（HSV - 2）Fc受体（FcR）与纯化的兔非免疫IgG及纯化的Fc结合的效果。纯化的Fc（75微克）或非免疫IgG（100微克）与HSV - 2结合时，不会降低其感染性，但能保护病毒粒子免受37℃的热灭活。然而，将这两种试剂与HSV - 2病毒粒子预温育，能显著保护其免受特异性抗HSV - 2 F(ab')2纯化兔抗血清的中和作用。HSV - 2病毒粒子上FcR - Fc相互作用所提供的中和阻断及热灭活保护作用，为解释病毒在免疫宿主体内的持续存在提供了一个合理的机制。
