大鼠大脑杏仁核中血管加压素结合位点的定位与特征分析
Localization and characterization of vasopressin-binding sites in the amygdala of the rat brain.
作者信息
Dorsa D M, Petracca F M, Baskin D G, Cornett L E
出版信息
J Neurosci. 1984 Jul;4(7):1764-70. doi: 10.1523/JNEUROSCI.04-07-01764.1984.
Abstract
Putative receptors for arginine-vasopressin (AVP) in rat brain were localized and characterized using autoradiographic and radioligand-binding techniques. When brain slices were incubated with tritium-labeled vasopressin, an intense concentration of binding sites was identified which included the medial aspects of the amygdala. Binding of labeled AVP to membrane preparations from this brain region was saturable, specific, reversible, and of high affinity. An antagonist of the peripheral pressor activity of vasopressin was found to be a potent competitor for binding to this site.
摘要
运用放射自显影和放射性配体结合技术，对大鼠脑中精氨酸加压素（AVP）的假定受体进行了定位和特性研究。当脑切片与氚标记的加压素一起孵育时，发现了一个结合位点的高浓度区域，其中包括杏仁核的内侧部分。标记的AVP与该脑区膜制剂的结合具有饱和性、特异性、可逆性且亲和力高。发现一种加压素外周升压活性的拮抗剂是与该位点结合的有效竞争者。
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