Kachru R B, Sequeira W, Mittal K K, Siegel M E, Telischi M
J Rheumatol. 1984 Aug;11(4):471-4.
We found a highly significant increase in the incidence of HLA-DR3 and DR2 antigens in black patients with systemic lupus erythematosus (SLE). HLA-DR3 was found in 62% of patients and 20% of controls (p less than 0.0001), and DR2 in 41% of patients and 18% of controls (p less than 0.001). The relative risk (RR), conferred by DR3 was 6.41, and that by DR2 was 3.03. Further, 84% of the patients had DR3 and/or DR2; the combined RR for SLE with these antigens was 9.0. A significant proportion of the patients (57%) developed lymphocytotoxic antibodies; of these, 19% had HLA specific antibodies.
我们发现，系统性红斑狼疮（SLE）黑人患者中HLA - DR3和DR2抗原的发生率显著升高。62%的患者存在HLA - DR3，而对照组中这一比例为20%（p小于0.0001）；41%的患者存在DR2，对照组中为18%（p小于0.001）。DR3赋予的相对风险（RR）为6.41，DR2赋予的相对风险为3.03。此外，84%的患者具有DR3和/或DR2；携带这些抗原的SLE患者的综合RR为9.0。相当一部分患者（57%）产生了淋巴细胞毒性抗体；其中，19%具有HLA特异性抗体。
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