Sanfilippo F, Croker B P
Transplantation. 1983 Jan;35(1):25-9. doi: 10.1097/00007890-198301000-00006.
A 38-year-old male with a 5-year history of dialysis-dependent renal failure secondary to membranoproliferative glomerulonephritis, type I, received a cadaveric renal allograft from a 51-year-old male dying from acute trauma. A pretransplant biopsy of the donor kidney revealed no glomerular disease. One month after transplantation, the patient was discharged with a stable creatinine of less than 2.0 mg/dl, but subsequently developed positive urine cultures for Staphylococcus aureus and Escherichia coli and eventually underwent transplant nephrectomy. Blood cultures were positive postoperatively for S. aureus, and examination of the transplant nephrectomy showed ultrastructural, histological, and immunofluorescent findings characteristic of postinfectious glomerulonephritis. While numerous types of glomerular disease have been reported in kidney transplants, this report represents the first case suggestive of bacterial postinfectious type glomerulonephritis we have seen occurring de novo in a renal allograft.
一名38岁男性，因I型膜增生性肾小球肾炎导致依赖透析的肾衰竭已有5年病史，接受了一名因急性创伤死亡的51岁男性的尸体肾移植。供体肾移植前活检未发现肾小球疾病。移植后一个月，患者肌酐稳定在2.0 mg/dl以下出院，但随后尿培养金黄色葡萄球菌和大肠杆菌呈阳性，最终接受了移植肾切除术。术后血培养金黄色葡萄球菌呈阳性，移植肾切除术检查显示有感染后肾小球肾炎的超微结构、组织学和免疫荧光特征。虽然肾移植中已报道了多种类型的肾小球疾病，但本报告是我们首次见到的提示细菌感染后型肾小球肾炎在同种异体肾移植中新生的病例。
