奎尼丁用药期间的心室颤动——奎尼丁晕厥（作者译）

[Ventricular fibrillation under quinidine medication--quinidine syncope (author's transl)].

作者信息

Aldor E, Heeger H

出版信息

Med Klin. 1978 Mar 3;73(9):325-8.

Abstract

Ventricular fibrillation which may occur unexpected under quinidine medication--called quinidine syncope--is one of the most dangerous complications of quinidine application. These life threatening accidents occur in 0,5-4,4% treated cases. The quinidine syncope occurs mostly at the attempt to eliminate atrial fibrillation or flutter. This dangerous side effect is dose independent. The ECG shows an increased QT duration and large U-waves. It seems to be a reentry-tachycardia caused by unequal recovery times in different parts of the ventricular myocardium.

摘要

在奎尼丁用药过程中可能意外发生的心室颤动——称为奎尼丁晕厥——是应用奎尼丁最危险的并发症之一。这些危及生命的意外事件发生在0.5% - 4.4%的治疗病例中。奎尼丁晕厥大多发生在试图消除心房颤动或心房扑动时。这种危险的副作用与剂量无关。心电图显示QT间期延长和巨大U波。它似乎是由心室心肌不同部位恢复时间不均等引起的折返性心动过速。