正常妊娠期间血浆肾素活性（PRA）、血管紧张素I和胎盘亮氨酸氨肽酶（P-LAP）活性的变化。

Changes in plasma renin activity (PRA), angiotensin I and placental leucine aminopeptidase (P-LAP) activity during normal pregnancy.

作者信息

Mizutani S, Sakura H, Akiyama H, Kobayashi H

出版信息

Nihon Sanka Fujinka Gakkai Zasshi. 1983 Apr;35(4):545-9.

Abstract

Plasma renin activity (PRA) and relative changes in angiotensin I compared with non-pregnant women were determined by radioimmunoassay (RIA) at different stages of normal gestation. Their levels showed increases in the early and late stages, and decreases at the period of 25 to 28 weeks of pregnancy in the middle stage, although their levels were higher than those in non-pregnant women throughout pregnancy. The increase in angiotensin I was less striking than that of PRA. Placental leucine aminopeptidase (P-LAP) activity increased progressively with advancing gestation, reaching the highest value at the 38th week of pregnancy. Simultaneous estimations of changes in angiotensin I and placental leucine aminopeptidase (P-LAP) were performed longitudinally in 12 normal pregnant women. The significance of the increase in P-LAP activity and the relationships among PRA, angiotensin I and P-LAP during normal pregnancy are discussed.

摘要

采用放射免疫分析法（RIA）测定正常妊娠不同阶段孕妇的血浆肾素活性（PRA）以及与未孕女性相比血管紧张素I的相对变化。结果显示，其水平在妊娠早期和晚期升高，妊娠中期25至28周时降低，不过在整个孕期其水平均高于未孕女性。血管紧张素I的升高不如PRA明显。胎盘亮氨酸氨肽酶（P-LAP）活性随孕周增加而逐渐升高，在妊娠第38周时达到最高值。对12名正常孕妇进行了血管紧张素I和胎盘亮氨酸氨肽酶（P-LAP）变化的纵向同步测定。文中讨论了正常妊娠期间P-LAP活性升高的意义以及PRA、血管紧张素I和P-LAP之间的关系。