蛋白质结合多面体硼烷

Protein-binding polyhedral boranes.

作者信息

Sneath R L, Wright J E, Soloway A H, O'Keefe S M, Dey A S, Smolnycki W D

出版信息

J Med Chem. 1976 Nov;19(11):1290-4. doi: 10.1021/jm00233a007.

Abstract

A series of polyhedral borane derivatives containing protein-binding functional groups has been synthesized. Problems encountered in earlier studies (low incorporation levels, gross precipitation of conjugates) have been overcome by including a water-solubilizing gluconamide group in the structure. This modification has allowed high levels of boron to be covalently bound to HGG, forming a completely water-soluble conjugate.

摘要

一系列含有蛋白质结合官能团的多面体硼烷衍生物已被合成。早期研究中遇到的问题（掺入水平低、缀合物大量沉淀）已通过在结构中引入水溶性葡糖酰胺基团得以克服。这种修饰使得高水平的硼能够共价结合到HGG上，形成一种完全水溶性的缀合物。