Senter T P, Stimson D H, Charles G, Brand R J
West J Med. 1983 Nov;139(5):657-62.
In a masked, randomized, concurrently controlled clinical trial we compared the therapeutic response of two regimens in which the same topical corticoid was used to treat 52 men who had stable psoriasis. One regimen, called reduced dose, consisted of once-a-day application of a representative potent fluorinated topical steroid ointment, fluocinonide (Lidex), combined with three-times-a-day application of its vehicle. The other regimen, called traditional dose, consisted of four-times-a-day topical application of the same steroid. Patients were assigned to one of the two regimens and observed for six weeks. Confidence intervals for the difference in true mean response under these two regimens provide good evidence that for these patients the traditional dose was not clinically superior to the reduced dose.
在一项双盲、随机、同期对照临床试验中，我们比较了两种治疗方案的疗效。这两种方案均使用同一种外用皮质类固醇治疗52例病情稳定的银屑病男性患者。一种方案称为减量方案，包括每日一次外用一种代表性的强效含氟外用类固醇软膏氟轻松（利德思），并联合每日三次外用其基质。另一种方案称为传统剂量方案，包括每日四次外用同一种类固醇。患者被分配至两种方案之一，并观察六周。这两种方案下真实平均反应差异的置信区间提供了充分证据，表明对于这些患者而言，传统剂量在临床上并不优于减量方案。
