接受妥布霉素-头孢呋辛或妥布霉素-青霉素G治疗的患者的肾功能。
Renal function in patients treated with tobramycin-cefuroxime or tobramycin-penicillin G.
作者信息
Trollfors B, Alestig K, Rödjer S, Sandberg T, Westin J
出版信息
J Antimicrob Chemother. 1983 Dec;12(6):641-5. doi: 10.1093/jac/12.6.641.
In order to evaluate the potentiating effect of cefuroxime on tobramycin nephrotoxicity 21 immunocompromised patients with suspected septicaemia were randomized to treatment with either tobramycin + cefuroxime or tobramycin + penicillin G. 51Chromium-EDTA clearance, serum creatinine, serum beta 2-microglobulin, urinary, alanine aminopeptidase, urinary N-acetyl-beta-D-glucosaminidase and urinary beta 2-microglobulin were measured during a nine day course of the antibiotic combinations. Enzymuria and a small but significant decrease of 51Chromium-EDTA clearance of equal magnitude in both treatment groups occurred. However the results cannot be extrapolated to other doses and treatment times than used in the study.
为了评估头孢呋辛对妥布霉素肾毒性的增强作用，将21例疑似败血症的免疫功能低下患者随机分为两组，分别接受妥布霉素+头孢呋辛或妥布霉素+青霉素G治疗。在为期九天的抗生素联合治疗过程中，测量了51铬-乙二胺四乙酸清除率、血清肌酐、血清β2-微球蛋白、尿丙氨酸氨基肽酶、尿N-乙酰-β-D-氨基葡萄糖苷酶和尿β2-微球蛋白。两个治疗组均出现酶尿，且51铬-乙二胺四乙酸清除率均有小幅但显著的同等程度下降。然而，这些结果不能外推至本研究以外的其他剂量和治疗时间。
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