Mannoji H, Takeshita I, Fukui M, Kitamura K
No To Shinkei. 1983 Dec;35(12):1207-16.
Sixteen cases of CNS hemangioblastoma were examined for glial fibrillary acidic protein (GFAP) using the immunoperoxidase method. In 13 cases GFAP-positive cells were found in the tumor. In all positive cases reactive gliosis in the form of trapped reactive astrocytes and their cytoplasmic processes penetrated the margin of the tumor. In 4 of the positive cases GFAP-positive cells were present deep in the tumor. Aggregates of GFAP-positive cells and fibrils were especially prominent in a recurrent case. Because hemangioblastomas grow without capsule into the cerebellar tissue, it is considered that reactive astrocytes and their fibrils are easily included and trapped within the tumor. In two cases GFAP-positive plump stromal cells, which were definitely different from the reactive astrocytes, were seen. They were neighbored with the dense gliotic foci or on and around the microcyst wall. This may be interpreted as that the stromal cells have a capacity to incorporate the extracellular GFAP derived from the intratumoral gliotic foci or cysts.
采用免疫过氧化物酶法对16例中枢神经系统血管母细胞瘤进行胶质纤维酸性蛋白（GFAP）检测。13例肿瘤中发现GFAP阳性细胞。在所有阳性病例中，以被困的反应性星形胶质细胞及其胞质突起形式存在的反应性胶质增生穿透肿瘤边缘。4例阳性病例中，GFAP阳性细胞存在于肿瘤深部。在1例复发病例中，GFAP阳性细胞和纤维聚集体尤为突出。由于血管母细胞瘤无包膜地生长进入小脑组织，因此认为反应性星形胶质细胞及其纤维容易被肿瘤包绕和捕获。2例中可见GFAP阳性的丰满基质细胞，它们与反应性星形胶质细胞明显不同。它们紧邻致密的胶质增生灶或位于微囊壁上及其周围。这可以解释为基质细胞具有摄取源自肿瘤内胶质增生灶或囊肿的细胞外GFAP的能力。
