Bito L Z
Exp Eye Res. 1984 Feb;38(2):181-94. doi: 10.1016/0014-4835(84)90102-7.
It has recently been shown that prostaglandin (PG)E2 or F2 alpha reduces the intraocular pressure (IOP) of cats and primates when applied topically to the eye in very small doses, and that reduced IOP can be maintained in these species as long as the topical application of one of these PGs is repeated daily or twice daily. In the present study the ocular hypotensive efficacy and some of the ocular side-effects of 15 eicosanoids and related compounds, especially derivatives of PGF2 alpha, were compared and were also compared to some clinically used ocular hypotensive agents. Derivatives of PGF2 alpha were found that had short-term and long-term ocular hypotensive potencies some 10- to 50-fold greater than PGF2 alpha itself.
最近有研究表明，前列腺素（PG）E2或F2α以非常小的剂量局部应用于眼部时，可降低猫和灵长类动物的眼压（IOP），并且只要每天或每天两次重复局部应用这些PG中的一种，这些物种的眼压降低就能得以维持。在本研究中，比较了15种类二十烷酸及其相关化合物，特别是PGF2α衍生物的降眼压效果和一些眼部副作用，同时也与一些临床使用的降眼压药物进行了比较。发现PGF2α衍生物的短期和长期降眼压效力比PGF2α本身大约高10至50倍。
