Saruta T, Fujimaki M, Senba S, Saito I, Konishi K
J Lab Clin Med. 1984 Jun;103(6):848-53.
Plasma levels of aldosterone and other mineralocorticoids were determined in six patients with Bartter's syndrome. In spite of a remarkable elevation of plasma renin activity, the plasma aldosterone and 18-hydroxycorticosterone levels varied in each patient. These levels were slightly increased in three of the six patients, almost normal in two patients, and slightly reduced in one patient. The plasma deoxycorticosterone and corticosterone levels were within the normal range in all patients. The responses of plasma aldosterone to infusion of angiotensin II were reduced in all patients. Plasma aldosterone and 18-hydroxycorticosterone significantly increased with supplement of potassium, and the responses of plasma aldosterone to infusion of angiotensin II were also improved after supplement of potassium. Our results suggest that plasma aldosterone in Bartter's syndrome is dependent on potassium balance, even though plasma renin activity is remarkably increased, and that hyperaldosteronism is not an inevitable finding in Bartter's syndrome.
对6例巴特综合征患者测定了血浆醛固酮及其他盐皮质激素水平。尽管血浆肾素活性显著升高，但每位患者的血浆醛固酮和18 - 羟皮质酮水平各不相同。6例患者中有3例这些水平略有升高，2例基本正常，1例略有降低。所有患者的血浆脱氧皮质酮和皮质酮水平均在正常范围内。所有患者血浆醛固酮对血管紧张素II输注的反应均降低。补充钾后，血浆醛固酮和18 - 羟皮质酮显著升高，补充钾后血浆醛固酮对血管紧张素II输注的反应也有所改善。我们的结果表明，尽管血浆肾素活性显著升高，但巴特综合征患者的血浆醛固酮依赖于钾平衡，而且高醛固酮血症并非巴特综合征的必然表现。
