George G, Hook G E
Environ Health Perspect. 1984 Apr;55:227-37. doi: 10.1289/ehp.8455227.
The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the pulmonary extracellular lining may underlie some disease conditions induced by toxic agents, especially those which interfere with the formation of pulmonary surfactant. The extracellular lining could be used to detect and monitor damage and disease caused by agents toxic to the lungs. The lining contains many hydrolytic enzymes which may act to detoxify certain toxic agents such as those which contain ester groups. The pulmonary extracellular lining could play a significant role mediating the toxic action of inhaled agents as well as the removal of those agents from the lungs.
对肺的细胞外衬层进行了综述。肺细胞外衬层是磷脂、蛋白质和碳水化合物的复杂混合物,对于维持正常肺功能(如气体交换)绝对至关重要。没有该衬层,肺就会塌陷。肺细胞外衬层的改变可能是某些由有毒物质引起的疾病状况的基础,尤其是那些干扰肺表面活性物质形成的物质。细胞外衬层可用于检测和监测由肺部有毒物质引起的损伤和疾病。该衬层含有许多水解酶,这些酶可能起到使某些有毒物质(如含有酯基的物质)解毒的作用。肺细胞外衬层在介导吸入物质的毒性作用以及将这些物质从肺中清除方面可能发挥重要作用。