Kubota H, Taguchi Y, Tohyama M, Matsuura N, Shiosaka S, Ishihara T, Watanabe T, Shiotani Y, Wada H
Gastroenterology. 1984 Sep;87(3):496-502.
The localization of histidine decarboxylase-like immunoreactive structures in the mucosal cells of the rat stomach was studied by the peroxidase-antiperoxidase method. At the light microscopic level, histidine decarboxylase-like immunoreactivity-containing cells were concentrated in the basal part of the oxyntic region, whereas in other areas no immunoreactive cells were seen. Ultrastructural study showed that reaction end products were diffusely distributed within the cytoplasm of the enterochromaffinlike cells but other cell types such as A cells, G cells, and enterochromaffin cells were not labeled. These findings suggest that enterochromaffinlike cells synthesize histamine.
采用过氧化物酶-抗过氧化物酶法研究了大鼠胃黏膜细胞中组氨酸脱羧酶样免疫反应性结构的定位。在光镜水平上，含组氨酸脱羧酶样免疫反应性的细胞集中在胃底腺区的基部，而在其他区域未见免疫反应性细胞。超微结构研究表明，反应终产物弥散分布于肠嗜铬样细胞的胞质内，但A细胞、G细胞和肠嗜铬细胞等其他细胞类型未被标记。这些发现提示肠嗜铬样细胞合成组胺。
