Dermis ageing.

On ageing major changes within connective components of the dermis can be seen: collagen looses its regular and fascicular appearance, while ground substance increases, elastic material decreases and the fibroblast cell population becomes "at rest". The resulting dermal ageing is different according to individuals and is related to genetic back ground and exposition to multiple aggressions. This review presents these changes of the superficial dermis and the role of fibroblasts in the conservation of the connective tissue integrity.