伴有IgM沉积的系膜增生性肾小球肾炎。临床病理分析及形态学转变证据

Mesangial proliferative glomerulonephritis with IgM deposits. Clinicopathologic analysis and evidence for morphologic transitions.

作者信息

Hirszel P, Yamase H T, Carney W R, Galen M A, Graeber C W, Johnson K J, Kennedy T L, Lapkin R A, McLean R H, Rosenworcel E

出版信息

Nephron. 1984;38(2):100-8. doi: 10.1159/000183289.

DOI:10.1159/000183289

PMID:6382035

Abstract

To determine the natural history of mesangial proliferative glomerulonephritis (MesPGN) with IgM deposits and its relationship to minimal change disease (MC) and focal segmental glomerulosclerosis (FGS), we studied the clinical characteristics and outcome in 20 patients with MesPGN, 8 with MC, and 10 with FGS. IgM deposits were present in glomeruli of all MesPGN patients. Progression to FGS was documented in 2 patients with MesPGN, 1 of whom developed renal failure. Transition from MC to MesPGN occurred in 1 patient. 2 MC patients developed FGS, with decline in renal function in 1 of them. These data suggest the possibility of histologic transition from MC to FGS directly or through the stage of MesPGN.

摘要

为了确定伴有IgM沉积的系膜增生性肾小球肾炎（MesPGN）的自然病程及其与微小病变病（MC）和局灶节段性肾小球硬化（FGS）的关系，我们研究了20例MesPGN患者、8例MC患者和10例FGS患者的临床特征及转归。所有MesPGN患者的肾小球均有IgM沉积。2例MesPGN患者进展为FGS，其中1例发展为肾衰竭。1例患者从MC转变为MesPGN。2例MC患者发展为FGS，其中1例肾功能下降。这些数据提示了从MC直接或通过MesPGN阶段向FGS进行组织学转变的可能性。