Danielsen H, Pedersen E B, Spencer E S
Br J Clin Pharmacol. 1984 Aug;18(2):229-31. doi: 10.1111/j.1365-2125.1984.tb02458.x.
The effect of indapamide, 2.5 mg daily, on blood pressure, electrolyte balance and the renin-aldosterone system was studied in 11 patients with essential hypertension. During indapamide treatment blood pressure decreased and the renin-aldosterone system was stimulated. A moderate hypokalaemia seen during indapamide treatment was not correlated to changes in plasma aldosterone concentration. Fractional excretion of potassium was unchanged during treatment, while renal calcium excretion was reduced. No effect on calcium in serum was observed.
对11例原发性高血压患者研究了每日服用2.5毫克吲达帕胺对血压、电解质平衡及肾素-醛固酮系统的影响。在吲达帕胺治疗期间,血压下降,肾素-醛固酮系统受到刺激。吲达帕胺治疗期间出现的中度低钾血症与血浆醛固酮浓度的变化无关。治疗期间钾的分数排泄未改变,而肾钙排泄减少。未观察到对血清钙的影响。