Shuklinov V A
Eksp Onkol. 1984;6(6):25-30.
It is emphasized that one of signs of malignant growth is heterogeneity of cell population which arises at the earliest pretumour stages and determines the character of tumour progression. At the same time by means of selective influences on population of malignant cells it is possible to change their quantitative correlation and to obtain rearrangement of the normal cell interrelations. Initiation of the tumour, its progression and regression are considered on the basis of the population-cell rearrangement, typical of each of them separately. The concept of the unity of the carcinogenesis and anticarcinogenesis processes is also formulated.
需要强调的是,恶性生长的标志之一是细胞群体的异质性,这种异质性在肿瘤前期最早阶段就已出现,并决定了肿瘤进展的特征。同时,通过对恶性细胞群体的选择性影响,有可能改变它们的数量关系,并使正常细胞的相互关系发生重排。肿瘤的发生、进展和消退是基于各自典型的群体细胞重排来考虑的。还提出了致癌过程与抗癌过程统一性的概念。