年龄对门诊患者锂盐疗效及副作用的影响。

The influence of age on lithium efficacy and side-effects in out-patients.

作者信息

Murray N, Hopwood S, Balfour D J, Ogston S, Hewick D S

出版信息

Psychol Med. 1983 Feb;13(1):53-60. doi: 10.1017/s0033291700050066.

Abstract

One hundred and sixty-six unipolar and bipolar out-patients (21-78 years) on long-term lithium treatment were studied on a prospective basis. Although there was a possible tendency for manic attacks to increase in prevalence and severity with age, it was difficult to demonstrate a general age-related decline in lithium efficacy. There was a tendency for the prevalence and severity of fine hand tremor to increase with age. This was not seen with polydipsia/polyuria, the other typical lithium side-effect.

摘要

对166名接受长期锂盐治疗的单相和双相情感障碍门诊患者（年龄在21岁至78岁之间）进行了前瞻性研究。尽管躁狂发作的患病率和严重程度可能有随年龄增加的趋势，但很难证明锂盐疗效存在与年龄相关的普遍下降。手部细微震颤的患病率和严重程度有随年龄增加的趋势。而多饮/多尿这种另一种典型的锂盐副作用则未出现这种情况。