碘帕醇与甲泛葡胺在脊髓造影中影像学质量及不良反应的比较。

Comparison of radiographic quality and adverse reactions in myelography with iopamidol and metrizamide.

作者信息

Bannon K R, Braun I F, Pinto R S, Manuell M, Sudilovsky A, Kricheff I I

出版信息

AJNR Am J Neuroradiol. 1983 May-Jun;4(3):312-3.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8334946/

Abstract

A randomized double-blind study was conducted to compare the radiographic quality and adverse reactions in myelography of the two nonionic water-soluble contrast media, iopamidol and metrizamide. A total of 46 myelograms were obtained, 28 with iopamidol and 18 with metrizamide. Untoward reactions consisted of nausea, headaches, back and leg pain, neuropsychiatric findings, and urinary retention. Iopamidol caused no reactions in 20 of the 28 cases, while metrizamide caused no reactions in only three of 18 cases. Film quality evaluation showed 22 of the 28 studies with iopamidol were judged excellent, whereas only 11 of the 18 metrizamide studies were judged excellent. The results of this study suggest that iopamidol produces better quality studies with fewer and milder adverse reactions than metrizamide.

摘要

进行了一项随机双盲研究，以比较两种非离子水溶性造影剂碘帕醇和甲泛葡胺在脊髓造影中的影像学质量和不良反应。共获得46例脊髓造影图像，其中28例使用碘帕醇，18例使用甲泛葡胺。不良反应包括恶心、头痛、背部和腿部疼痛、神经精神方面的表现以及尿潴留。28例使用碘帕醇的病例中有20例未出现反应，而18例使用甲泛葡胺的病例中只有3例未出现反应。胶片质量评估显示，28例使用碘帕醇的研究中有22例被判定为优秀，而18例使用甲泛葡胺的研究中只有11例被判定为优秀。本研究结果表明，与甲泛葡胺相比，碘帕醇产生的研究质量更好，不良反应更少且更轻微。