Murphy H M, Wideman C H, Long D W, Brown T S
Peptides. 1983 Sep-Oct;4(5):735-7. doi: 10.1016/0196-9781(83)90028-1.
The first experiment was conducted in an attempt to ascertain the effects of hippocampal lesions on plasma levels of total T4, total T3, free T4, and TSH. Animals with hippocampal lesions had significantly lower levels of total T4, free T4 and TSH than cortical control and normal animals. There were no significant differences in total T3 among the three groups. Since these results indicated that animals with hippocampal lesions manifested a dysfunction in the hypothalamic-pituitary-thyroid axis, a second experiment was undertaken to determine the site of mediation. A TRH injection test demonstrated that the dysfunction occurs at the level of the hypothalamus. It is hypothesized that in the normal animal the hippocampus exerts a facilitating effect on the hypothalamic-pituitary-thyroid axis.
第一个实验旨在确定海马体损伤对血浆总甲状腺素（T4）、总三碘甲状腺原氨酸（T3）、游离甲状腺素（T4）和促甲状腺激素（TSH）水平的影响。与皮质对照动物和正常动物相比，海马体损伤的动物总T4、游离T4和TSH水平显著降低。三组动物的总T3水平无显著差异。由于这些结果表明海马体损伤的动物下丘脑 - 垂体 - 甲状腺轴存在功能障碍，因此进行了第二个实验以确定介导部位。促甲状腺激素释放激素（TRH）注射试验表明功能障碍发生在下丘脑水平。据推测，在正常动物中，海马体对下丘脑 - 垂体 - 甲状腺轴具有促进作用。
