Pignol B, Bourbon J, Rieutort M
C R Seances Acad Sci III. 1983;297(6):339-42.
Phosphatidylglycerol and phosphatidylinositol were studied on gestational day 21.5 in the lung of Rat fetuses from streptozotocin-diabetic mothers (severe diabetes; maternal glycemia, 16.5 16.5 mmol/l). A 55% decrease of phosphatidylglycerol and a concomitant 60% increase of phosphatidylinositol were shown. These changes are qualitatively similar to those previously observed in amniotic fluid of human fetuses from diabetic mothers. Since in the severely diabetic pregnant Rat, the fetuses present hyperglycemia and hypoinsulinemia, instead of reactional hyperinsulinemia as the human fetus does, the changes observed in fetal lung are probably due to a direct effect of glucose excess, possibly through an increase of blood myoinositol.
在妊娠第21.5天，对链脲佐菌素诱导的糖尿病母亲（严重糖尿病；母体血糖，16.5 mmol/l）所产大鼠胎儿的肺组织中的磷脂酰甘油和磷脂酰肌醇进行了研究。结果显示，磷脂酰甘油减少了55%，同时磷脂酰肌醇增加了60%。这些变化在性质上与先前在糖尿病母亲所产人类胎儿羊水中观察到的变化相似。由于在严重糖尿病的妊娠大鼠中，胎儿表现为高血糖和低胰岛素血症，而不像人类胎儿那样出现反应性高胰岛素血症，因此在胎儿肺中观察到的变化可能是由于葡萄糖过量的直接作用，可能是通过血液中肌醇的增加所致。
