大鼠和小鼠大脑中的胰岛素样免疫反应性。出生后个体发育过程中的急剧下降。
Cerebral insulin-like immunoreactivity in rats and mice. Drastic decline during postnatal ontogenesis.
作者信息
Bernstein H G, Dorn A, Reiser M, Ziegler M
出版信息
Acta Histochem. 1984;74(1):33-6. doi: 10.1016/S0065-1281(84)80022-7.
PMID:6428131
Abstract
We studied the behavior of the insulin-like immunoreactivity in brains of rats and mice during the first 20 d post natum by immunohistochemistry and radioimmunoassay. It was found that a dramatic decline in the concentration of the peptide, accompanied by a strong reduction of immunoreactive cells, takes place during this period. A possible role of cerebral insulin as a promoter of nerve cell growth and development is briefly discussed.
摘要
我们通过免疫组织化学和放射免疫测定法研究了大鼠和小鼠出生后前20天大脑中胰岛素样免疫反应性的行为。结果发现，在此期间，该肽的浓度急剧下降，同时免疫反应性细胞大量减少。本文简要讨论了脑胰岛素作为神经细胞生长和发育促进剂的可能作用。
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