孕晚期重复（三次）注射促黄体激素释放激素/促甲状腺激素释放激素后催乳素、促甲状腺激素、促卵泡激素、β-人绒毛膜促性腺激素和雌三醇的反应

Prl, TSH, FSH, beta-hCG and oestriol responses to repetitive (triple) LRH/TRH administration in the third trimester of human pregnancy.

作者信息

Pérez-López F R, Robert J, Teijeiro J

出版信息

Acta Endocrinol (Copenh). 1984 Jul;106(3):400-4. doi: 10.1530/acta.0.1060400.

DOI:10.1530/acta.0.1060400

Abstract

The effects of repetitive administration of 50 micrograms of LRH and 100 micrograms of TRH in a single bolus at 0, 90 and 180 min on Prl, TSH, FSH, beta-hCG and oestriol were tested in 11 healthy pregnant women in their third trimester of pregnancy. Basal hormonal levels were in agreement with previous reports. The Prl and TSH peaks after each injection of LRH/TRH were similar for each hormone. No significant changes in serum FSH, beta-hCG and oestriol were detected after repetitive administration of LRH/TRH. Thus, the responsiveness of lactotroph and thyrotroph cells to pulsatile stimulation with LRH/TRH is not altered during the last trimester of pregnancy, and FSH, beta-hCG and oestriol levels remain constant during the period of sampling.

摘要

在11名妊娠晚期的健康孕妇中，测试了在0、90和180分钟时单次推注50微克促黄体激素释放激素（LRH）和100微克促甲状腺激素释放激素（TRH）对催乳素（Prl）、促甲状腺激素（TSH）、促卵泡激素（FSH）、β-人绒毛膜促性腺激素（β-hCG）和雌三醇的重复给药效果。基础激素水平与先前报道一致。每次注射LRH/TRH后，每种激素的Prl和TSH峰值相似。重复给药LRH/TRH后，未检测到血清FSH、β-hCG和雌三醇有显著变化。因此，在妊娠晚期，催乳细胞和促甲状腺细胞对LRH/TRH脉冲刺激的反应性未改变，且在采样期间FSH、β-hCG和雌三醇水平保持恒定。