人类白细胞抗原表型与胰岛素抗体产生
HLA phenotype and insulin antibody production.
作者信息
Reeves W G, Gelsthorpe K, Van der Minne P, Torensma R, Tattersall R B
出版信息
Clin Exp Immunol. 1984 Aug;57(2):443-8.
Abstract
HLA phenotypes have been determined in 79 patients as part of a prospective study of factors governing the immune response to injected insulin. IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia haemocyanin, suggests the presence of an immune response gene for insulin. The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a non-specific abnormality of immunity.
摘要
作为一项关于影响胰岛素注射免疫反应因素的前瞻性研究的一部分，已对79例患者进行了HLA表型测定。在开始使用牛胰岛素治疗6个月后，携带HLA - DR7的患者中IgG胰岛素抗体水平显著更高，并且鉴于对玛瑙螺血蓝蛋白的IgG反应缺乏类似模式，提示存在胰岛素免疫反应基因。HLA - B8/DR3/C4AQ0阳性个体的低反应性更可能反映免疫的非特异性异常。
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