脑室内降钙素基因相关肽抑制胃酸分泌。

Intraventricular calcitonin gene-related peptide inhibits gastric acid secretion.

作者信息

Hughes J J, Levine A S, Morley J E, Gosnell B A, Silvis S E

出版信息

Peptides. 1984 Jul-Aug;5(4):665-7. doi: 10.1016/0196-9781(84)90003-2.

Abstract

Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide recently demonstrated to be a peptide expressed by the calcitonin gene in the rat central nervous system. Intracerebroventricular administration of CGRP in pylorus ligated rats resulted in a dose dependent suppression of gastric acid secretion. This effect was also present in acutely vagotomized rats. In addition, CGRP inhibited the stimulation of gastric acid secretion by thyrotropin releasing hormone. CGRP was considerably less potent in its effect on gastric acid than calcitonin, a well known central inhibitor of gastric acid secretion in the rat. This study suggests that CGRP may be a factor in the central regulation of gastric acid secretion in the rat.

摘要

降钙素基因相关肽（CGRP）是一种由37个氨基酸组成的肽，最近被证明是大鼠中枢神经系统中由降钙素基因表达的一种肽。在幽门结扎的大鼠中脑室内注射CGRP可导致胃酸分泌呈剂量依赖性抑制。这种效应在急性迷走神经切断的大鼠中也存在。此外，CGRP抑制促甲状腺激素释放激素对胃酸分泌的刺激作用。与降钙素相比，CGRP对胃酸的作用效力要低得多，而降钙素是大鼠胃酸分泌的一种众所周知的中枢抑制剂。这项研究表明，CGRP可能是大鼠胃酸分泌中枢调节中的一个因素。