Sartani A, de Pasqua A, Cesati R, Farina L, Pontiroli A E
Horm Metab Res. 1984 Oct;16(10):535-8. doi: 10.1055/s-2007-1014843.
Metergoline, a prolactin (PRL)-lowering drug with an antiserotoninergic activity, is known to restore menstruations and fertility in hyper-PRL patients even when PRL levels are not normalized. This suggests that metergoline might also affect gonadotropins release. In a double-blind cross-over study in 8 normal males, repeated administration of metergoline enhanced the LH response to LHRH and reduced the PRL response to TRH; for females, three different tests were performed on days 5, 8 and 21 of two different menstrual cycles, each test being preceded by metergoline or by placebo administration. Metergoline always reduced the PRL response to TRH; on the 5th day, metergoline reduced the FSH response to LHRH and on the 21st day enhanced the LH response to LHRH. Basal levels of LH, FSH, T3, T4, Testosterone, 17 beta-estradiol and progesterone as well as the FSH response to LHRH (in males) and the TSH response to TRH (in both males and females) were not modified by metergoline. The data suggest that tests with TRH and LHRH can yield different results when performed during metergoline administration and that metergoline, acting through an unknown mechanism, can modify gonadotropins release.
麦角苄酯是一种具有抗血清素能活性的降低催乳素（PRL）的药物，已知即使在PRL水平未恢复正常时，它也能使高PRL患者恢复月经和生育能力。这表明麦角苄酯可能也会影响促性腺激素的释放。在一项针对8名正常男性的双盲交叉研究中，重复给予麦角苄酯可增强LH对LHRH的反应，并降低PRL对TRH的反应；对于女性，在两个不同月经周期的第5、8和21天进行了三项不同的测试，每项测试前均给予麦角苄酯或安慰剂。麦角苄酯总是能降低PRL对TRH的反应；在第5天，麦角苄酯降低了FSH对LHRH的反应，而在第21天增强了LH对LHRH的反应。麦角苄酯未改变LH、FSH、T3、T4、睾酮、17β-雌二醇和孕酮的基础水平，以及FSH对LHRH的反应（男性）和TSH对TRH的反应（男性和女性）。数据表明，在服用麦角苄酯期间进行TRH和LHRH测试可能会产生不同的结果，并且麦角苄酯通过未知机制发挥作用，可改变促性腺激素的释放。
