Sansone G, Reali S, Sansone R, Allegranza F
Acta Haematol. 1984;72(4):285-7. doi: 10.1159/000206402.
In a 36-month-old child a severe hemolytic anemia occurred after the administration of a pyrazolonic drug. Erythrocyte glucose-6-phosphate dehydrogenase activity was absent in the patient. Intermediate enzymatic levels were demonstrated in the mother and in the maternal grand-mother with a corresponding erythrocyte mosaicism at the methemoglobin elution test. Some cells showed Heinz bodies and peculiar changes in the morphology in the initial phase of the crisis. There is no mention in the literature of a hemolytic action of this drug.
一名36个月大的儿童在服用一种吡唑啉酮类药物后发生了严重的溶血性贫血。该患者红细胞葡萄糖-6-磷酸脱氢酶活性缺乏。母亲和外祖母的酶水平处于中间状态，高铁血红蛋白洗脱试验显示相应的红细胞镶嵌现象。在危机初期，一些细胞出现海因茨小体和形态上的特殊变化。文献中未提及该药物的溶血作用。
