聚氰基丙烯酸酯纳米颗粒与肝细胞的毒性及相关性

Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes.

作者信息

Kreuter J, Wilson C G, Fry J R, Paterson P, Ratcliffe J H

机构信息

Department of Pharmaceutics, Swiss Federal Institute of Technology ETH, Zurich.

出版信息

J Microencapsul. 1984 Jul-Sep;1(3):253-7. doi: 10.3109/02652048409049364.

DOI:10.3109/02652048409049364

PMID:6443850

Abstract

The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepatocytes were 0.4 mg/2 x 10(6) cells and greater than 1 mg/2 x 10(6) cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation.

摘要

测定了聚氰基丙烯酸丁酯（PBC）和聚氰基丙烯酸己酯（PHC）纳米颗粒的降解情况，以及它们与分离的肝细胞的结合和对肝细胞的毒性。纳米颗粒未被大鼠肝细胞大量摄取。PBC和PHC纳米颗粒对肝细胞的半数致死剂量分别为0.4毫克/2×10⁶个细胞和大于1毫克/2×10⁶个细胞。这种肝细胞毒性不能仅归因于降解过程中形成的甲醛。