Kenny D A, Berger K, Walker M W, Robel S B, Boguslavsky L, Ray L I, Lischko M M, Sauvage L R
Ann Surg. 1980 Mar;191(3):355-61. doi: 10.1097/00000658-198003000-00016.
Two types of 4 mm ID prostheses were studied in the carotid arteries of the dog. These were noncrimped polypropylene-supported filamentous velour knitted Dacron (PPSFV) and expanded polytetrafluoroethylene (e-PTFE, Gore-Tex). Thrombus-"Free" Surface TFS) areas and patency rates were determined at the end of the implant periods. One series of implants was subjected to controlled low flow rates for six hours; another was exposed to physiologic flow rates and observed at seven days, 14 days, and 12 weeks. At six hours the filamentous Dacron, preclotted according to a specific regimen utilizating heparin, performed as well as, and possibly better than, e-PTFE. The Gore-Tex developed surface coagulum in an irregular fashion which was related to graft wetting and blood soakage. Seven-day TFS scores and patency rates of the two graft types were comparable at physiologic flow rates. At two weeks, TFS scores and patency rates of the two graft types were comparable at physiologic flow rates. At two weeks, TFS scores and patency rates dropped. This was sufficiently marked in the case of e-PTFE that longer-term implants were not done. However, PPSFV grafts were implanted for 12 weeks, and all grafts examined at that time had closed. It appears that patency of 4 mm ID grafts of this construction will not be reliably attained in the dog carotid artery without the use of platelet-inhibitory drugs until complete healing has occurred.
在犬的颈动脉中研究了两种内径为4毫米的假体。它们分别是未卷曲的聚丙烯支撑的丝状绒面针织涤纶（PPSFV）和膨体聚四氟乙烯（e-PTFE，戈尔特斯）。在植入期结束时测定血栓-“无”表面（TFS）面积和通畅率。一组植入物在可控的低流速下放置6小时；另一组暴露于生理流速下，并在7天、14天和12周时进行观察。在6小时时，按照使用肝素的特定方案预凝血的丝状涤纶表现与e-PTFE一样好，甚至可能更好。戈尔特斯以不规则的方式形成表面凝块，这与移植物湿润和血液浸润有关。在生理流速下，两种移植物类型的7天TFS评分和通畅率相当。在两周时，两种移植物类型的TFS评分和通畅率相当。在两周时，TFS评分和通畅率下降。在e-PTFE的情况下，这种下降足够明显，以至于没有进行长期植入。然而，PPSFV移植物植入了12周，当时检查的所有移植物都已闭合。看来，在犬颈动脉中，如果不使用血小板抑制药物，直到完全愈合，这种结构的内径4毫米移植物的通畅性将无法可靠实现。
