Gille J
Fortschr Med. 1980 Apr 24;98(16):621-5.
Immunofluorescent findings are revealing EPH-gestosis as an immunological disease similar to graft rejection. Deposits of immunoglobulins, complement, and fibrinogen/fibrin are localized in the glomerular capillaries, mesangium of the kidney and in the decidual arteries resembling findings in transplanted organs with signs of rejection. Fibrinoid changes of the villous stroma are found in greater amounts in placentae after gestosis revealing a more lively humoral reaction of the immune system. By mixed lymphocyte culture a cellular hyperreactivity of the mother against her fetus can be demonstrated. In conclusion, gestosis is a disease of humoral and cellular hyperreactivity finally resulting in the well-known peripheral symptoms edema, hypertension, and proteinuria. Early diagnosis followed by an effective therapy is desirable in preventing these secondary effects.
免疫荧光检查结果显示，妊娠高血压综合征是一种类似于移植排斥反应的免疫性疾病。免疫球蛋白、补体以及纤维蛋白原/纤维蛋白的沉积物定位在肾小球毛细血管、肾脏系膜以及蜕膜动脉中，这类似于移植器官出现排斥反应的表现。妊娠高血压综合征后胎盘绒毛间质的纤维样变性更为常见，这揭示了免疫系统更活跃的体液反应。通过混合淋巴细胞培养可以证明母亲对胎儿存在细胞高反应性。总之，妊娠高血压综合征是一种体液和细胞高反应性疾病，最终导致众所周知的外周症状，如水肿、高血压和蛋白尿。为预防这些继发效应，早期诊断并进行有效治疗是可取的。
