Ito Y, Ebisawa K, Kira Y, Koizumi T
Adv Myocardiol. 1980;1:509-18.
Turnover rates and synthesis of cardiac structural proteins were studied in normal and hypertrophied rabbit heart. The order of incorporation rates of radioactive lysine in normal heart was: left ventricular greater than right ventricular greater than atrial greater than skeletal myosin B. In left ventricular muscle, the order of relative turnover rates of structural proteins was: native tropomyosin greater than the complex of 10 S-actinin and alpha-actinin greater than myosin heavy chain greater than myosin light chain greater than (soluble protein) greater than actin. After aortic constriction (to three-fourths of its original circumference), the rates of incorporation of radioactive lysine into each structural protein fraction increased, reaching a peak on the 7th day. The values returned to the levels of the normal group after 1 month. It was noted that the increase of incorporation into native tropomyosin was greater than the other structural proteins 7 days after constriction.
在正常和肥大的兔心脏中研究了心脏结构蛋白的周转率和合成情况。正常心脏中放射性赖氨酸的掺入率顺序为：左心室大于右心室大于心房大于骨骼肌肌球蛋白B。在左心室肌中，结构蛋白的相对周转率顺序为：天然原肌球蛋白大于10S - 辅肌动蛋白和α - 辅肌动蛋白复合物大于肌球蛋白重链大于肌球蛋白轻链大于（可溶性蛋白）大于肌动蛋白。主动脉缩窄（至其原始周长的四分之三）后，放射性赖氨酸掺入每个结构蛋白组分的速率增加，在第7天达到峰值。1个月后这些值恢复到正常组水平。值得注意的是，缩窄7天后天然原肌球蛋白的掺入增加量大于其他结构蛋白。
