成人T细胞白血病中的14号染色体长臂增加

A 14q+ chromosome in adult T-cell leukemia.

作者信息

Miyamoto K, Sato J, Kitajima K, Hamazaki K, Adachi T, Sato T, Noda N, Hioka H, Sanada H, Tanaka T, Taguchi H

出版信息

Acta Med Okayama. 1981 Feb;35(1):19-25. doi: 10.18926/AMO/31291.

Abstract

Chromosome studies were conducted on two patients with adult T-cell leukemia. In both patients, a marker chromosome 14q+ and a structural change involving chromosome 1 with trisomy of the q arm were found in peripheral blood leukocytes. The 14q+ marker chromosome had resulted from translocation from #5p in one patient and #5q in the other patient. The present and previous studies suggest that the donor chromosomes involved in the 14q+ translocation are variable. This indicates that the 14q+ marker chromosome rather than the donor chromosome is intimately related with adult T-cell leukemia.

摘要

对两名成人T细胞白血病患者进行了染色体研究。在两名患者的外周血白细胞中均发现了一条标记染色体14q +以及涉及1号染色体的结构改变，伴有q臂三体。在一名患者中，14q +标记染色体是由5号染色体短臂易位所致，而在另一名患者中则是由5号染色体长臂易位所致。目前及既往研究表明，参与14q +易位的供体染色体是可变的。这表明14q +标记染色体而非供体染色体与成人T细胞白血病密切相关。