Schumacher G E, Griener J C
Am J Hosp Pharm. 1978 Apr;35(4):454-9.
A modification of the superposition method, which yields fast and reasonably accurate estimates of dosage regimens and steady-state maximum and minimum blood levels, is described. In the modified superposition method, input data are obtained from the blood, plasma or serum concentration vs time profile resulting from administration of a single dose of the drug. These estimates are valid only when the pharmacokinetics of the drugs are linear and elimination from the body occurs according to first-order kinetics. Limitations of the method are discussed. It is concluded that this is a rapid and clinically useful method for pharmacokinetic estimations.
本文描述了一种叠加法的改进方法，该方法能快速且合理准确地估算给药方案以及稳态血药浓度的最大值和最小值。在改进的叠加法中，输入数据取自单次给药后血药、血浆或血清浓度随时间变化的曲线。这些估算仅在药物的药代动力学呈线性且机体按一级动力学消除时才有效。文中讨论了该方法的局限性。得出的结论是，这是一种用于药代动力学估算的快速且临床实用的方法。
