Gosden R G, Hawkins H K, Gosden C A
Am J Pathol. 1978 Apr;91(1):155-74.
Smooth muscle tissue collected from the uterine fundus of 24 patients undergoing hysterectomy was examined for chromolipoid pigments by histochemical and electron microscopic techniques. Certain cytoplasmic particles were found, mainly in smooth muscle cells, which exhibited characteristic autofluorescence, sudanophilia, and acid phosphatase activity but did not correspond to any typical pigment described previously. These particles were present in all subjects and they tended to increase in number with age. Chemical tests on tissue lipid extracts failed to prove that vitamin A was responsible for the fluorescence. The ultrastructural appearance of the particles somewhat variable, but most particles were rounded and of low electron density, with a lucent central space and dense bodies, probably lysosomes, at the periphery. The whole complex was enclosed by a single trilaminar membrane.
采用组织化学和电子显微镜技术，对24例接受子宫切除术患者子宫底的平滑肌组织进行了类色素检查。发现某些细胞质颗粒，主要存在于平滑肌细胞中，这些颗粒呈现出特征性的自发荧光、嗜苏丹性和酸性磷酸酶活性，但与先前描述的任何典型色素均不相符。所有受试者均存在这些颗粒，且其数量有随年龄增加的趋势。对组织脂质提取物进行的化学检测未能证明维生素A是产生荧光的原因。这些颗粒的超微结构外观有些变化，但大多数颗粒呈圆形，电子密度低，中央有透明空间，周边有致密小体，可能是溶酶体。整个复合体被一层单膜包绕。
