Poon T K, Cameron D P
Am J Physiol. 1978 May;234(5):E532-4. doi: 10.1152/ajpendo.1978.234.5.E532.
Oxygen consumption and locomotor activity were studied in mice developing obesity after neonatal administration of monosodium glutamate (MSG) and in untreated controls. MSG-treated mice became obese in the absence of increased food intake. Locomotor activity was significantly less in MSG-treated mice 2, 10, and 20 wk after weaning. Oxygen consumption expressed in terms of the Lee index was not significantly different at 2 wk after weaning although at 10 and 20 wk it was significantly lower in MSG-treated mice. Plasma thyroxine was not different between MSG-treated and control mice. It is suggested that diminished energy expenditure is the major factor in the etiology of obesity after neonatal administration of MSG.
研究了新生期给予味精（MSG）后发生肥胖的小鼠以及未处理的对照小鼠的耗氧量和运动活性。接受MSG处理的小鼠在没有增加食物摄入量的情况下变得肥胖。断奶后2周、10周和20周时，接受MSG处理的小鼠的运动活性明显较低。以Lee指数表示的耗氧量在断奶后2周时，MSG处理组和对照组之间没有显著差异，尽管在10周和20周时，MSG处理组小鼠的耗氧量显著降低。MSG处理组和对照小鼠之间的血浆甲状腺素没有差异。提示能量消耗减少是新生期给予MSG后肥胖病因中的主要因素。
